None of these work while you're typing in a box (chat, a search, a name), or while Ctrl, Alt or Cmd is held, so they never get in the way of your browser's shortcuts.
The keys are yours to change: Settings, Keys. Click a line and press the new key. If another action already uses that key, the two swap. This page shows your own keys.
Moving and fighting
Key
Does
WASD or the arrow keys
Walk. Holding a key keeps walking. A click on the ground or on anything walks you there and does it.
1234
Your ability bar's four slots: the ability goes off on your next swing. Right-click a slot to switch its auto off and on.
ZXCV
Use your quick slots: a potion, food, a buff, arrows, or a piece of gear (press again to take it off). Press and hold a slot, or right-click it, to change what is in it. The Store sells up to four more, each on its own key: 5678.
E
Eat the best cooked food in your bag, whatever heals most. Smoked fish count (they heal more since 1.9). It never touches potions, drinks or buff meals, and does nothing at full health.
B
Use every buff loaded in your Buff Bag, when it is in your bag.
Windows
Key
Does
IUKJL
The tabs over your inventory: Inventory, Equipment, Skills, Quests, and your Diary (it opens on the map you're standing on).
F
Your Character window: every number about you, and where to get more.
Q
The quest log.
T
Open or close the chat.
Enter
Open the chat with the cursor in the box; Enter again sends.
G
The games: every table in the casino, in one list.
Y
Achievements.
P
The Kennel: your pets.
O
The Workbench: your rolled pieces, charts and pet artifacts, and every ink you can use on them, anywhere (Rolled loot).
- and =, or the mouse wheel
Zoom out to see more of the map, or in for a closer look (also the buttons by the minimap). Your zoom is remembered on that computer. Not on a phone.
H or ?
This wiki.
M
Mute or unmute every sound, the jukebox included.
N
The connection panel: your ping, for when something feels laggy.
Esc
Close whatever is open: a window, a conversation, the item info box, or the chat box.
Talking to people
Key
Does
1 to 9
Pick that answer. While somebody is talking to you the number keys answer them and do not use your ability bar or quick slots, whichever keys they are on.
Space
Carry on, when there is only one answer.
With the mouse
Do this
To
Shift-click in your bag
Drop it (it asks first, unless you turned that off in Settings).
Ctrl-click (Cmd on a Mac) a piece of gear in your bag or on your doll
Link it in chat: its name goes into the box in brackets, and everyone can point at it to see its stats, lines and how many times it has been worked on. On a phone, hold it and pick Link in chat.
Right-click any item
Open its page in this wiki.
Shift-click in the bank
Take out a full stack, or put in every one you carry.